Spectrophotometric Determination of Nitroxoline in Medicines Using the Response Surface Methodology
https://doi.org/10.26907/2542-064X.2023.1.118-132
Abstract
It was shown by the conductometric study that the formation of micelles in the cetyltrimethylammonium bromide (CTAB) – dimethylsulfoxide (DMSO) – water system occurs at higher critical micelle concentrations (CMC) than in the CTAB – water system. The solubilization of nitroxoline in this system upon reaching the CMC was determined by the spectrophotometric method. The Box–Behnken design was used to obtain systems with the highest light absorption of nitroxoline, depending on the CTAB concentration, the acidity of the pH medium, and the proportion of DMSO when searching for the optimal matrix. A sensitive and selective technique suitable for micellar media and spectrophotometric analysis was developed using the response surface methodology for the determination of nitroxoline in medicines.
About the Authors
R. F. Bakeeva
Kazan National Research Technological University
Russian Federation
Russian Federation
Kazan, 420015
S. Yu. Garmonov
Kazan National Research Technological University
Russian Federation
Russian Federation
Kazan, 420015
V. D. Osipova
Kazan National Research Technological University
Russian Federation
Russian Federation
Kazan, 420015
K. V. Chernyj
Kazan National Research Technological University
Russian Federation
Russian Federation
Kazan, 420015
S. Yu. Mamykina
Kazan National Research Technological University
Russian Federation
Russian Federation
Kazan, 420015
V. F. Sopin
Kazan National Research Technological University
Russian Federation
Russian Federation
Kazan, 420015
References
1. Strachunskii L.S., Belousov Yu.B., Kozlov S.N. (Eds.) Prakticheskoe rukovodstvo po antiinfektsionnoi khimioterapii [A Practical Guide to Anti-Infective Chemotherapy]. Smolensk, Mezhreg. Assots. Klin. Microbiol. Antimikrob. Khimioter., 2007. 462 p. (In Russian)
2. Rosen M.J. Surfactants and Interfacial Phenomena. New York, John Wiley & Sons, 2004. 457 p. doi: 10.1002/0471670561.
3. Abe M., Scamehorn J.F. (Eds.) Mixed Surfactant Systems. CRC Press, 2004. 831 p. doi: 10.1201/9781420031010.
4. Savvin S.B., Chernova R.K., Shtykov S.N. Poverkhnostno-aktivnye veshchestva [Surfactants]. Moscow, Nauka, 1991. 251 p. (In Russian)
5. Rusanov A.I. Mitselloobrazovanie v rastvorakh poverkhnostno-aktivnykh veshchestv [Micellization in Solutions of Surfactants]. St. Petersburg, Khimiya, 1992. 280 p. (In Russian)
6. Patil A.S., Pethe A.M. Quality by Design (QbD): A new concept for development of quality pharmaceuticals. Int. J. Pharm. Qual. Assur., 2013, vol. 4, no. 2, pp. 13–19.
7. Lawrence X.Yu. Pharmaceutical quality by design: Product and process development, understanding, and control. Pharm. Res., 2008, vol. 25, no. 4, pp. 781–791. doi: 10.1007/s11095-008-9667-3.
8. Ferreira S.L.C., Bruns R.E., Ferreira H.S., Matos G.D., David J.M., Brandão G.C., da Silva E.G.P., Portugal L.A., dos Reisc P.S., Souza A.S., dos Santos W.N.L. Box–Behnken design: An alternative for the optimization of analytical methods. Anal. Chim. Acta., 2007, vol. 597, no. 2, pp. 179–186. doi: 10.1016/j.aca.2007.07.011.
9. de Oliveira F.S., Korn M. Spectrophotometric determination of sulphate in automotive fuel ethanol by sequential injection analysis using dimethylsulphonazo(III) reaction. Talanta, 2005, vol. 68, no. 3. pp. 992–999. doi: 10.1016/j.talanta.2005.06.055.
10. Bakeeva R.F., Garmonov S.Yu., Vakhitova O.E., Sopin V.F. Determination of amine-containing drugs in micellar matrices by spectrophotometry using Box–Behnken Plans. J. Anal. Chem., 2022, vol. 77, no. 6, pp. 688–697. doi: 10.31857/S0044450222060032.
11. Bakeeva R.F., Vakhitova O.E., Garmonov S.Yu., Sopin V.F. Design of a micellar matrix for the determination of o-phenylenediamine in dosage forms by the spectrophotometric method. Planning and optimization. Zhidk. Krist. Ikh Prakt. Ispol’z., 2022, vol. 22, no. 2, pp. 19–31. doi: 10.18083/LCAppl.2022.2.19. (In Russian)
12. Bakeeva R.F., Garmonov S.Yu., Karimullina A.A., Sopin V.F. Using the response surface method for the spectrophotometric determination of 4-aminophenol in drugs. Uchenye Zapiski Kazanskogo Universiteta. Seriya Estestvennye Nauki, 2022, vol. 164, no. 3, pp. 367–377. doi: 10.26907/2542064X.2022.3.367-377. (In Russian)
13. Shtykov S.N. Surfactants in analysis: Progress and development trends. J. Anal. Chem., 2000, vol. 55, no. 7. pp. 608–614. doi: 10.1007/BF02827992.
14. Adler Yu.P., Markova E.V., Granovskii Yu.V. Planirovanie eksperimenta pri poiske optimal’nykh uslovii [Planning an Experiment in the Search for Optimal Conditions]. Moscow, Nauka, 1976. 279 p. (In Russian)
15. Box G.E.P., Hunter J.S., Hunter W.G. Statistics for Experimenters. Design, Innovation, and Discovery. New York, Wiley-Interscience, 2005. 672 p.
Review
For citations:
Bakeeva R.F., Garmonov S.Yu., Osipova V.D., Chernyj K.V., Mamykina S.Yu., Sopin V.F. Spectrophotometric Determination of Nitroxoline in Medicines Using the Response Surface Methodology. Uchenye Zapiski Kazanskogo Universiteta Seriya Estestvennye Nauki. 2023;165(1):118–132. (In Russ.) https://doi.org/10.26907/2542-064X.2023.1.118-132
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