Selective Voltammetric Determination of Paracetamol and Acyclovir on an Electrode Modified with Reduced Graphene Oxide and Gold Particles
https://doi.org/10.26907/2542-064X.2024.3.401-413
Abstract
The electrooxidation of acyclovir (ACv) and paracetamol (PC) on a glassy carbon electrode (GCE) coated with reduced graphene oxide (GOred) and electrodeposited gold particles (Au/GOred/GCE) was studied. The separation of the oxidation peaks of PC and ACv on the Au/GOred/GCE was achieved by decreasing overvoltage. А selective and highly sensitive voltammetric method for the simultaneous determination of PC and ACv was developed. The linear dynamic range of PC and ACv was from 5×10-3 to 5×10-8 M. The proposed method was successfully applied to detect non-metabolized forms of PC and ACv in the presence of human urine.
About the Authors
L. G. Shaidarova
Kazan Federal University
Russian Federation
Competing Interests:
Russian Federation
Kazan, 420008.
Competing Interests:
The authors declare no conflicts of interest.
A. A. Pozdnyak
Kazan Federal University
Russian Federation
Competing Interests:
Russian Federation
Kazan, 420008.
Competing Interests:
The authors declare no conflicts of interest.
A. V. Gedmina
Kazan Federal University
Russian Federation
Competing Interests:
Russian Federation
Kazan, 420008.
Competing Interests:
The authors declare no conflicts of interest.
H. C. Budnikov
Kazan Federal University
Russian Federation
Competing Interests:
Russian Federation
Kazan, 420008.
Competing Interests:
The authors declare no conflicts of interest.
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Review
For citations:
Shaidarova L.G., Pozdnyak A.A., Gedmina A.V., Budnikov H.C. Selective Voltammetric Determination of Paracetamol and Acyclovir on an Electrode Modified with Reduced Graphene Oxide and Gold Particles. Uchenye Zapiski Kazanskogo Universiteta Seriya Estestvennye Nauki. 2024;166(3):401-413. (In Russ.) https://doi.org/10.26907/2542-064X.2024.3.401-413
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