uzakuescУченые записки Казанского университета. Серия Естественные наукиUchenye Zapiski Kazanskogo Universiteta Seriya Estestvennye Nauki2542-064X2500-218XKazan (Volga Region) Federal University10.26907/2542-064X.2026.1.42-74uzakuesc-494Research ArticleСтатьиАнализ сетей коэкспрессии генов и белок–белковых взаимодействий с участием натрий-зависимого фосфатного транспортера NaPi2b в нормальных и опухолевых тканях яичникаAnalysis of gene co-expression and protein–protein interaction networks involving the sodium-dependent phosphate transporter NaPi2b in ovarian normal and tumor tissueshttps://orcid.org/0000-0003-0082-6833ВласенковаР. А.VlasenkovaR. A.

Рамиля Ахметовна Власенкова - научный сотрудник НИЛ «Биомаркер», Институт фундаментальной медицины и биологии.

Казань

Ramilia A. Vlasenkova - Researcher, “Biomarker” Research Laboratory, Institute of Fundamental Medicine and Biology.

Kazan

r.mukhamadeeva@yandex.ruФилюшинаК. И.FilyushinaK. I.

Ксения Игоревна Филюшина - студент, Институт фундаментальной медицины и биологии.

Казань

Kseniya I. Filyushina - Student, Institute of Fundamental Medicine and Biology.

Kazan

filyushina.k@mail.ruhttps://orcid.org/0000-0002-2547-2843КиямоваР. Г.KiyamovaR. G.

Рамзия Галлямовна Киямова - доктор биологических наук, старший научный сотрудник, заведующий кафедрой биохимии, биотехнологии и фармакологии, главный научный сотрудник, руководитель НИЛ «Биомаркер», Институт фундаментальной медицины и биологии.

Казань

Ramziya G. Kiyamova - Dr. Sci. (Biology), Senior Researcher, Head of Department of Biochemistry, Biotechnology, and Pharmacology, Chief Researcher, “Biomarker” Research Laboratory, Institute of Fundamental Medicine and Biology.

Kazan

kiyamova@mail.ruКазанский (Приволжский) федеральный университетРоссияKazan Federal UniversityRussian Federation20260103202616814274Copyright © Власенкова Р.А., Филюшина К.И., Киямова Р.Г., 20262026Власенкова Р.А., Филюшина К.И., Киямова Р.Г.Vlasenkova R.A., Filyushina K.I., Kiyamova R.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://uzakuesc.elpub.ru/jour/article/view/494

Исследование посвящено сравнительному анализу сетей коэкспрессии гена SLC34A2 натрий-зависимого фосфатного транспортера NaPi2b с генами гликозил- и сульфотрансфераз и взаимодействия продуктов этих генов в нормальных и опухолевых клетках яичника для выявления белков, ответственных за аберрантное гликозилирование транспортера NaPi2b при злокачественной трансформации клеток. Данные по экспрессии 214 генов гликозил- и сульфотрансфераз и гена SLC34A2 в нормальных и опухолевых клетках были получены из исследования E-MTAB-3732 (ArrayExpress, n = 579), а данные о 7025 белок–белковых взаимодействиях из открытых баз данных. Построенные на основе собранных данных сети показали различия в паттернах коэкспрессии генов и взаимодействия их продуктов. Коэффициент кофенетической корреляции сетей в нормальных и опухолевых клетках яичника составил 0.17. Ключевые гены B3GNT2, GCNT1, ST3GAL1, ST6GAL1 входят в состав крупнейшего модуля вместе с геном SLC34A2 в сети коэкспрессии генов и белок–белковых взаимодействий в опухолях. Сделано предположение, что профили экспрессии и взаимодействий продуктов генов ST6GAL1, B3GNT2, GCNT1, ST3GAL1 могут быть связаны с аномальным гликозилированием NaPi2b в опухолевых клетках. Дальнейшие исследования этих белков важны для понимания роли гликозилирования в изменениях конформации большого внеклеточного домена транспортера NaPi2b и разработки противоопухолевых препаратов против потенциального опухоль-специфического эпитопа МХ35 транспортера NaPi2b.

A comparative analysis was carried out to explore the co-expression networks of the SLC34A2 gene, which encodes the sodium-dependent phosphate transporter NaPi2b, with glycosyl- and sulfotransferase genes and the interaction between the products of these genes in ovarian normal and tumor cells in order to identify proteins responsible for aberrant glycosylation of the NaPi2b transporter in malignant cell transformation. Data on the expression of 214 glycosyl- and sulfotransferase genes and the SLC34A2 gene in ovarian normal and tumor cells were obtained from the E-MTAB-3732 dataset (ArrayExpress, n = 579), and data on 7025 protein–protein interactions were sourced from open-access databases. The networks constructed using the collected data revealed differences in the patterns of gene co-expression and the interaction of their products. The cophenetic correlation coefficient of the networks in ovarian normal and tumor cells was 0.17. The key genes B3GNT2, GCNT1, ST3GAL1, and ST6GAL1 were found to be part of the largest module together with SLC34A2 in the network of gene co-expression and protein–protein interactions in ovarian tumor cells. The results suggest that the expression and interaction profiles of ST6GAL1, B3GNT2, GCNT1, and ST3GAL1 gene products may be associated with abnormal glycosylation of NaPi2b in ovarian tumor cells. Further research on these proteins will foster a better understanding of the role of glycosylation in conformational changes of the large extracellular domain of the NaPi2b transporter and may contribute to the development of anti-tumor drugs targeting the potential tumor-specific MX35 epitope of the NaPi2b transporter.

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The authors declare that there are no conflicts of interest present.